Research Articles
Evaluating Chaperone-Mediated Autophagy (CMA) in Neurodegenerative Models: A Comprehensive Guide for Researchers
This comprehensive guide provides researchers, scientists, and drug development professionals with a detailed framework for assessing Chaperone-Mediated Autophagy (CMA) activity in models of neurodegenerative diseases such as Alzheimer's, Parkinson's, and...
AI Protein Folding Showdown 2024: Benchmarking AlphaFold2, RoseTTAFold, and ESMFold for Research & Drug Discovery
This comprehensive benchmark analysis provides researchers, scientists, and drug development professionals with a critical evaluation of the three leading AI-powered protein structure prediction tools: AlphaFold2, RoseTTAFold, and ESMFold.
Targeting Protein Misfolding in Hypoxic Tumors: Mechanisms, Therapeutic Strategies, and Clinical Implications
This article provides a comprehensive analysis of protein misfolding mechanisms within the hypoxic tumor microenvironment, a critical yet underexplored hallmark of cancer.
Bacterial Protein Degradation Strategies: From Proteolytic Systems to Advanced Recombinant Protein Production
This article provides a comprehensive overview of protein degradation in bacterial hosts, a critical challenge in biotechnology and therapeutic protein development.
ATP vs. ATP-Independent Chaperones: Energy-Dependent and Energy-Neutral Protein Folding Mechanisms in Health and Disease
This article provides a comprehensive analysis of ATP-dependent and ATP-independent molecular chaperone systems, tailored for researchers and drug development professionals.
ATP-Driven Protein Folding: The Molecular Mechanism and Biomedical Applications of Chaperonins
This article provides a comprehensive, state-of-the-art analysis of the ATP-dependent mechanism of chaperonins, essential molecular machines that facilitate protein folding in the cell.
Bacterial Protein Quality Control: The Essential Role of ATP-Dependent Chaperones and Proteases in Pathogen Survival
This article provides a comprehensive exploration of ATP-dependent chaperones and proteases as the core machinery of bacterial protein quality control (PQC).
ATP Hydrolysis as the Engine of Chaperone Disaggregation: Mechanisms, Methods, and Medical Implications
This article provides a comprehensive analysis of ATP hydrolysis as the fundamental power source for molecular chaperone-mediated disaggregation of protein aggregates, a critical process in cellular proteostasis.
Unfolding the ATF6-GRP78 Chaperone System: A Comprehensive Guide to Endoplasmic Reticulum Protein Folding and Stress Signaling
This article provides a detailed exploration of the ATF6-GRP78 chaperone system, a central regulator of endoplasmic reticulum (ER) proteostasis and the unfolded protein response (UPR).
The ARBRE-MOBIEU P4EU Framework: A Complete Guide to Protein Quality Guidelines for Biomedical Research & Drug Development
This comprehensive guide details the ARBRE-MOBIEU P4EU protein quality guidelines, a critical framework for researchers and drug developers.