Research Articles
Protein Integrity Verification by Mass Spectrometry: A Comprehensive Guide for Robust Biomolecular Analysis
This article provides a comprehensive guide to mass spectrometry (MS) methods for verifying protein integrity, a critical step in biomedical research and drug development.
Clearance Mechanisms of Protein Aggregation in Alzheimer's Disease: Pathways, Therapeutic Targeting, and Future Directions
This article provides a comprehensive analysis of protein aggregation clearance pathways in Alzheimer's disease, targeting researchers and drug development professionals.
Protein Quality Control: The Master Modulator of Bacterial Evolution and a New Frontier in Drug Development
This article synthesizes contemporary research on the bacterial Protein Quality Control (PQC) network, a system of chaperones, proteases, and translational machinery that maintains proteome homeostasis.
Strategies for Preventing Protein Aggregation: A Comprehensive Guide for Purification and Storage
This article provides a systematic guide for researchers and drug development professionals on mitigating protein aggregation, a critical challenge that compromises therapeutic efficacy and patient safety.
RP-HPLC vs. HPLC-ELSD for Protein Quantification: A Comprehensive Guide for Pharmaceutical Scientists
This article provides a systematic comparison of Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and HPLC coupled with Evaporative Light Scattering Detection (HPLC-ELSD) for protein quantification in pharmaceutical formulations.
Protein Stability Design: Advanced Methods to Boost Heterologous Expression for Research and Therapeutics
This article provides a comprehensive overview of modern computational and experimental strategies for designing protein stability to overcome the critical bottleneck of low yields in heterologous expression.
Validating Protein Stability Design: From Computational Methods to Cross-Family Applications
This article provides a comprehensive overview of the current landscape, methodologies, and validation frameworks for computational protein stability design.
Protein Quality in Plant vs. Animal Sources: A Scientific Analysis for Biohealth Applications
This article provides a comprehensive analysis of protein quality from plant and animal sources, tailored for researchers and drug development professionals.
Evolutionary Guardians of the Proteome: A Cross-Species Analysis of Protein Quality Control Pathways
This review provides a comprehensive comparative analysis of protein quality control (PQC) pathways across species, from yeast to humans.
Ensuring Lot-to-Lot Consistency in Protein Reagents: A Guide for Reproducible Research and Drug Development
This article addresses the critical challenge of lot-to-lot variability in protein reagent production, a major source of irreproducibility in biomedical research and a significant risk in diagnostic and therapeutic development.